Fludrocortisone Explained: What It Is, How to Use It, and What to Expect

If you’ve been handed a prescription for fludrocortisone, you probably have a lot of questions. In plain language, fludrocortisone is a synthetic version of a hormone your adrenal glands make naturally. That hormone, called aldosterone, helps your body hold onto salt and water, which in turn keeps your blood pressure steady.

Doctors usually prescribe fludrocortisone for people whose adrenal glands aren’t making enough aldosterone on their own. The most common reasons are Addison’s disease, certain forms of adrenal insufficiency, or after you’ve had surgery that affected your adrenal glands. It can also be part of the treatment plan for orthostatic hypotension—when you feel dizzy on standing because your blood pressure drops.

How to Take Fludrocortisone: Dosage Tips

Most adults start with a low dose, often between 0.05 mg and 0.2 mg taken once a day. Your doctor will adjust the amount based on blood pressure readings, sodium levels, and how you feel. It’s important to take the pill at the same time each day, preferably with food, to help your stomach absorb it better.

Don’t try to guess your dose. If you miss a dose, take it as soon as you remember—but if it’s almost time for your next pill, just skip the missed one and continue with your regular schedule. Doubling up can cause a sudden rise in blood pressure, which isn’t safe.

Side Effects and Safety: What to Watch For

Because fludrocortisone makes your body hold onto salt, you might notice swelling in your ankles or face. That’s a sign you may be keeping too much fluid, and you should let your doctor know right away. Other common side effects include headache, fatigue, and a feeling of “fullness” after meals.

Rare but serious reactions can happen, such as severe hypertension (high blood pressure) or a rapid heartbeat. If you experience chest pain, severe dizziness, or sudden weight gain, call your healthcare provider immediately.

Fludrocortisone can also interact with other medicines, especially diuretics (water pills) and certain blood pressure drugs. Always give your pharmacist a full list of what you’re taking, including over‑the‑counter supplements.

Here are a few practical tips to keep things running smoothly:

• Check your blood pressure at home regularly and keep a log for your doctor.
• Stay hydrated, but avoid excessive salty foods if you’re told to limit sodium.
• Tell your doctor about any new symptoms right away—not just the obvious ones.

Most people do well on fludrocortisone when they follow these simple guidelines. The medication helps balance electrolytes, which can make a huge difference in daily energy levels and overall well‑being.

Still have questions? Common FAQs include:

• Can I drink alcohol? A small amount is usually fine, but heavy drinking can worsen blood pressure swings.
• Will I need blood tests? Yes—your doctor will likely check sodium, potassium, and creatinine every few weeks until you’re stable.
• Can I become pregnant while on fludrocortisone? The drug is generally considered safe, but discuss any plans with your doctor to adjust the dose if needed.

Bottom line: fludrocortisone is a helpful tool for people whose bodies can’t regulate salt and water on their own. By taking it as prescribed, monitoring your blood pressure, and staying in touch with your healthcare team, you can keep symptoms in check and live a normal, active life.